2hfw: Difference between revisions
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==Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III== | |||
<StructureSection load='2hfw' size='340' side='right'caption='[[2hfw]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2hfw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HFW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfw OCA], [https://pdbe.org/2hfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hfw RCSB], [https://www.ebi.ac.uk/pdbsum/2hfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfw ProSAT]</span></td></tr> | ||
[[2hfw]] is a 1 chain structure | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CAH3_HUMAN CAH3_HUMAN] Reversible hydration of carbon dioxide. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/2hfw_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hfw ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Carbonic anhydrase|Carbonic anhydrase]] | *[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Elder | [[Category: Large Structures]] | ||
[[Category: Fisher | [[Category: Elder I]] | ||
[[Category: Laipis | [[Category: Fisher SZ]] | ||
[[Category: McKenna | [[Category: Laipis PJ]] | ||
[[Category: Silverman | [[Category: McKenna R]] | ||
[[Category: Tu | [[Category: Silverman DN]] | ||
[[Category: Tu CK]] | |||
Latest revision as of 09:32, 14 February 2024
Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III
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