2j7x: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(20 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2j7x.gif|left|200px]]<br />
<applet load="2j7x" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2j7x, resolution 2.10&Aring;" />
'''STRUCTURE OF ESTRADIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5'''<br />


==About this Structure==
==STRUCTURE OF ESTRADIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5==
2J7X is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with SO4, BCT, EST and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J7X OCA]].
<StructureSection load='2j7x' size='340' side='right'caption='[[2j7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
[[Category: Protein complex]]
== Structural highlights ==
<table><tr><td colspan='2'>[[2j7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J7X FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EST:ESTRADIOL'>EST</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7x OCA], [https://pdbe.org/2j7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j7x RCSB], [https://www.ebi.ac.uk/pdbsum/2j7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ESR2_RAT ESR2_RAT] Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER-alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/2j7x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j7x ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Bonn, T.]]
[[Category: Bonn T]]
[[Category: Brzozowski, A.M.]]
[[Category: Brzozowski AM]]
[[Category: Carlquist, M.]]
[[Category: Carlquist M]]
[[Category: Engstrom, O.]]
[[Category: Engstrom O]]
[[Category: Gustaffson, J.A.]]
[[Category: Gustaffson J-A]]
[[Category: Hubbard, R.E.]]
[[Category: Hubbard RE]]
[[Category: Ljunggren, J.]]
[[Category: Ljunggren J]]
[[Category: Pike, A.C.W.]]
[[Category: Pike ACW]]
[[Category: Thorsell, A.G.]]
[[Category: Thorsell A-G]]
[[Category: Walton, J.]]
[[Category: Walton J]]
[[Category: BCT]]
[[Category: EDO]]
[[Category: EST]]
[[Category: SO4]]
[[Category: activator]]
[[Category: alternative splicing]]
[[Category: coactivator]]
[[Category: corepressor]]
[[Category: dna-binding]]
[[Category: glycoprotein]]
[[Category: lipid-binding]]
[[Category: metal-binding]]
[[Category: nuclear protein]]
[[Category: nuclear receptor]]
[[Category: phosphorylation]]
[[Category: receptor]]
[[Category: repressor]]
[[Category: steroid-binding]]
[[Category: transcription]]
[[Category: transcription factor]]
[[Category: transcription regulation]]
[[Category: zinc]]
[[Category: zinc-finger]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:10:10 2007''
Retrieved from "https://proteopedia.org/2j7x"