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[[Image:1smc.png|left|200px]]


{{STRUCTURE_1smc|  PDB=1smc  |  SCENE=  }}
==Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.==
 
<StructureSection load='1smc' size='340' side='right'caption='[[1smc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1smc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SMC FirstGlance]. <br>
{{ABSTRACT_PUBMED_15276840}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUT:DEOXYURIDINE-5-TRIPHOSPHATE'>DUT</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1smc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smc OCA], [https://pdbe.org/1smc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1smc RCSB], [https://www.ebi.ac.uk/pdbsum/1smc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1smc ProSAT]</span></td></tr>
[[1smc]] is a 3 chain structure of [[Deoxyuridine 5'-triphosphate nucleotidohydrolase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMC OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sm/1smc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1smc ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
*[[DUTPase 3D structures|DUTPase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:015276840</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: DUTP diphosphatase]]
[[Category: Cascio D]]
[[Category: Cascio, D.]]
[[Category: Chan S]]
[[Category: Chan, S.]]
[[Category: Cho US]]
[[Category: Cho, U S.]]
[[Category: Eisenberg D]]
[[Category: Eisenberg, D.]]
[[Category: Kim C-Y]]
[[Category: Kim, C Y.]]
[[Category: Kim M-Y]]
[[Category: Kim, M Y.]]
[[Category: Krupka H]]
[[Category: Krupka, H.]]
[[Category: Lekin T]]
[[Category: Lekin, T.]]
[[Category: Naranjo CM]]
[[Category: Naranjo, C M.]]
[[Category: Park MS]]
[[Category: Park, M S.]]
[[Category: Pashkov I]]
[[Category: Pashkov, I.]]
[[Category: Perry JL]]
[[Category: Perry, J L.]]
[[Category: Rogers YC]]
[[Category: Rogers, Y C.]]
[[Category: Sawaya MR]]
[[Category: Sawaya, M R.]]
[[Category: Segelke B]]
[[Category: Segelke, B.]]
[[Category: So M]]
[[Category: So, M.]]
[[Category: Terwilliger TC]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Waldo GS]]
[[Category: Terwilliger, T C.]]
[[Category: Yeates TO]]
[[Category: Waldo, G S.]]
[[Category: Yeates, T O.]]
[[Category: Hydrolase]]
[[Category: Jelly-roll]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
Retrieved from "https://proteopedia.org/1smc"