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[[Image:2rdt.png|left|200px]]


{{STRUCTURE_2rdt|  PDB=2rdt  |  SCENE=  }}
==Crystal Structure of Human Glycolate Oxidase (GO) in Complex with CDST==
 
<StructureSection load='2rdt' size='340' side='right'caption='[[2rdt]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
===Crystal Structure of Human Glycolate Oxidase (GO) in Complex with CDST===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2rdt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RDT FirstGlance]. <br>
{{ABSTRACT_PUBMED_18215067}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2RD:5-(DODECYLTHIO)-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC+ACID'>2RD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rdt OCA], [https://pdbe.org/2rdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rdt RCSB], [https://www.ebi.ac.uk/pdbsum/2rdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rdt ProSAT]</span></td></tr>
[[2rdt]] is a 1 chain structure of [[Glycolate oxidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RDT OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rd/2rdt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rdt ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Glycolate oxidase|Glycolate oxidase]]
*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018215067</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Holmes, R P.]]
[[Category: Large Structures]]
[[Category: Lowther, W T.]]
[[Category: Holmes RP]]
[[Category: Murray, M S.]]
[[Category: Lowther WT]]
[[Category: Flavoprotein]]
[[Category: Murray MS]]
[[Category: Fmn]]
[[Category: Glycolate pathway]]
[[Category: Oxidoreductase]]
[[Category: Peroxisome]]
Retrieved from "https://proteopedia.org/2rdt"