1g4y: Difference between revisions

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[[Image:1g4y.png|left|200px]]


{{STRUCTURE_1g4y|  PDB=1g4y  |  SCENE=  }}
==1.60 A CRYSTAL STRUCTURE OF THE GATING DOMAIN FROM SMALL CONDUCTANCE POTASSIUM CHANNEL COMPLEXED WITH CALCIUM-CALMODULIN==
 
<StructureSection load='1g4y' size='340' side='right'caption='[[1g4y]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
===1.60 A CRYSTAL STRUCTURE OF THE GATING DOMAIN FROM SMALL CONDUCTANCE POTASSIUM CHANNEL COMPLEXED WITH CALCIUM-CALMODULIN===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1g4y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G4Y FirstGlance]. <br>
{{ABSTRACT_PUBMED_11323678}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g4y OCA], [https://pdbe.org/1g4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g4y RCSB], [https://www.ebi.ac.uk/pdbsum/1g4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g4y ProSAT]</span></td></tr>
[[1g4y]] is a 2 chain structure of [[Calmodulin]] and [[Potassium Channel]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G4Y OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/1g4y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g4y ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Calmodulin|Calmodulin]]
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
*[[Potassium Channel|Potassium Channel]]
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:011323678</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Adelman, J P.]]
[[Category: Adelman JP]]
[[Category: Bachinger, H P.]]
[[Category: Bachinger HP]]
[[Category: Rivard, A.]]
[[Category: Rivard A]]
[[Category: Schumacher, M A.]]
[[Category: Schumacher MA]]
[[Category: Calmodulin]]
[[Category: Channel gating]]
[[Category: Signaling protein]]
[[Category: Small-conductance calcium-activated potassium channel]]
Retrieved from "https://proteopedia.org/1g4y"