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[[Image:3d4p.png|left|200px]]


{{STRUCTURE_3d4p|  PDB=3d4p  |  SCENE=  }}
==Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus complexed with NAD and pyruvate==
 
<StructureSection load='3d4p' size='340' side='right'caption='[[3d4p]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus complexed with NAD and pyruvate===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3d4p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D4P FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
[[3d4p]] is a 2 chain structure of [[Lactate Dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_col Staphylococcus aureus subsp. aureus col]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D4P OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d4p OCA], [https://pdbe.org/3d4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d4p RCSB], [https://www.ebi.ac.uk/pdbsum/3d4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d4p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LDH1_STAAC LDH1_STAAC] Appears to be the primary factor that allows S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells.<ref>PMID:18356528</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/3d4p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d4p ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Lactate Dehydrogenase|Lactate Dehydrogenase]]
*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
[[Category: L-lactate dehydrogenase]]
== References ==
[[Category: Staphylococcus aureus subsp. aureus col]]
<references/>
[[Category: Almo, S C.]]
__TOC__
[[Category: Gutierrez, J A.]]
</StructureSection>
[[Category: Ho, M.]]
[[Category: Large Structures]]
[[Category: Schramm, V L.]]
[[Category: Staphylococcus aureus subsp. aureus COL]]
[[Category: Glycolysis]]
[[Category: Almo SC]]
[[Category: Lactate dehydrogenase]]
[[Category: Gutierrez JA]]
[[Category: Nad]]
[[Category: Ho M]]
[[Category: Oxidoreductase]]
[[Category: Schramm VL]]
[[Category: Phosphoprotein]]
[[Category: Pyruvate]]
[[Category: Staphylococcus aureus]]
Retrieved from "https://proteopedia.org/3d4p"