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[[Image:3gjr.png|left|200px]]


{{STRUCTURE_3gjr|  PDB=3gjr  |  SCENE=  }}
==Caspase-3 Binds Diverse P4 Residues in Peptides==
 
<StructureSection load='3gjr' size='340' side='right'caption='[[3gjr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
===Caspase-3 Binds Diverse P4 Residues in Peptides===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3gjr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GJR FirstGlance]. <br>
{{ABSTRACT_PUBMED_19283487}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DZE:METHYL+(3S)-3-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOPENTANOATE'>DZE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gjr OCA], [https://pdbe.org/3gjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gjr RCSB], [https://www.ebi.ac.uk/pdbsum/3gjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gjr ProSAT]</span></td></tr>
[[3gjr]] is a 4 chain structure of [[Caspase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJR OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/3gjr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gjr ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Caspase|Caspase]]
*[[Caspase 3D structures|Caspase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019283487</ref><references group="xtra"/>
__TOC__
[[Category: Caspase-3]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Agniswamy, J.]]
[[Category: Large Structures]]
[[Category: Fang, B.]]
[[Category: Agniswamy J]]
[[Category: Fu, G.]]
[[Category: Fang B]]
[[Category: Harrison, R W.]]
[[Category: Fu G]]
[[Category: Weber, I T.]]
[[Category: Harrison RW]]
[[Category: Apoptosis]]
[[Category: Weber IT]]
[[Category: Cysteine protease]]
[[Category: Enzyme catalysis]]
[[Category: Hydrolase]]
[[Category: Phosphoprotein]]
[[Category: Protease]]
[[Category: Protein recognition]]
[[Category: S-nitrosylation]]
[[Category: Thiol protease]]
[[Category: Zymogen]]
Retrieved from "https://proteopedia.org/3gjr"