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[[Image:3nzx.png|left|200px]]


{{STRUCTURE_3nzx|  PDB=3nzx  |  SCENE=  }}
==Crystal structure of the yeast 20S proteasome in complex with ligand 2c==
 
<StructureSection load='3nzx' size='340' side='right'caption='[[3nzx]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
===Crystal structure of the yeast 20S proteasome in complex with ligand 2c===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3nzx]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NZX FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABN:BENZYLAMINE'>ABN</scene>, <scene name='pdbligand=BOC:TERT-BUTYL+HYDROGEN+CARBONATE'>BOC</scene>, <scene name='pdbligand=RE3:3-[(3S)-3-HYDROXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-L-ALANINE'>RE3</scene>, <scene name='pdbligand=TY5:O-BENZYL-L-TYROSINE'>TY5</scene></td></tr>
[[3nzx]] is a 30 chain structure of [[Proteasome]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZX OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nzx OCA], [https://pdbe.org/3nzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nzx RCSB], [https://www.ebi.ac.uk/pdbsum/3nzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nzx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.


==See Also==
==See Also==
*[[Proteasome|Proteasome]]
*[[Proteasome 3D structures|Proteasome 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:020715286</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Proteasome endopeptidase complex]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Basse, N.]]
[[Category: Basse N]]
[[Category: Gallastegui, N.]]
[[Category: Gallastegui N]]
[[Category: Genin, E.]]
[[Category: Genin E]]
[[Category: Groll, M.]]
[[Category: Groll M]]
[[Category: Huber, R.]]
[[Category: Huber R]]
[[Category: Marechal, X.]]
[[Category: Le Ravalec V]]
[[Category: Moroder, M.]]
[[Category: Marechal X]]
[[Category: Ravalec, V Le.]]
[[Category: Moroder M]]
[[Category: Reboud-Ravaux, M.]]
[[Category: Reboud-Ravaux M]]
[[Category: Richy, N.]]
[[Category: Richy N]]
[[Category: Vidal, V.]]
[[Category: Vidal V]]
[[Category: 19s regulatory particle]]
[[Category: Cytosol]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: N-terminal nucleophilic hydrolase]]
[[Category: Nucleus]]
[[Category: Protein degradation]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin-tagged substrate]]
Retrieved from "https://proteopedia.org/3nzx"