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[[Image:1shg.png|left|200px]]


{{STRUCTURE_1shg|  PDB=1shg  |  SCENE=  }}
==CRYSTAL STRUCTURE OF A SRC-HOMOLOGY 3 (SH3) DOMAIN==
 
<StructureSection load='1shg' size='340' side='right'caption='[[1shg]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===CRYSTAL STRUCTURE OF A SRC-HOMOLOGY 3 (SH3) DOMAIN===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1shg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SHG FirstGlance]. <br>
{{ABSTRACT_PUBMED_1279434}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1shg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shg OCA], [https://pdbe.org/1shg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1shg RCSB], [https://www.ebi.ac.uk/pdbsum/1shg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1shg ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1shg]] is a 1 chain structure of [[Spectrin]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHG OCA].  
== Function ==
[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1shg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1shg ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Spectrin|Spectrin]]
*[[Spectrin 3D structures|Spectrin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:001279434</ref><ref group="xtra">PMID:011206053</ref><ref group="xtra">PMID:016477599</ref><references group="xtra"/>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Musacchio, A.]]
[[Category: Large Structures]]
[[Category: Noble, M.]]
[[Category: Musacchio A]]
[[Category: Pauptit, R.]]
[[Category: Noble M]]
[[Category: Saraste, M.]]
[[Category: Pauptit R]]
[[Category: Wierenga, R K.]]
[[Category: Saraste M]]
[[Category: Cytoskeleton]]
[[Category: Wierenga RK]]
Retrieved from "https://proteopedia.org/1shg"