1hti: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,609 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,609 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1hti.png|left|200px]]


{{STRUCTURE_1hti|  PDB=1hti  |  SCENE=  }}
==CRYSTAL STRUCTURE OF RECOMBINANT HUMAN TRIOSEPHOSPHATE ISOMERASE AT 2.8 ANGSTROMS RESOLUTION. TRIOSEPHOSPHATE ISOMERASE RELATED HUMAN GENETIC DISORDERS AND COMPARISON WITH THE TRYPANOSOMAL ENZYME==
 
<StructureSection load='1hti' size='340' side='right'caption='[[1hti]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
===CRYSTAL STRUCTURE OF RECOMBINANT HUMAN TRIOSEPHOSPHATE ISOMERASE AT 2.8 ANGSTROMS RESOLUTION. TRIOSEPHOSPHATE ISOMERASE RELATED HUMAN GENETIC DISORDERS AND COMPARISON WITH THE TRYPANOSOMAL ENZYME===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1hti]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HTI FirstGlance]. <br>
{{ABSTRACT_PUBMED_8061610}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hti OCA], [https://pdbe.org/1hti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hti RCSB], [https://www.ebi.ac.uk/pdbsum/1hti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hti ProSAT]</span></td></tr>
[[1hti]] is a 2 chain structure of [[TIM test]] and [[Triose Phosphate Isomerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTI OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.
== Function ==
[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/1hti_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hti ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[TIM test|TIM test]]
*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
*[[Triose Phosphate Isomerase|Triose Phosphate Isomerase]]
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:008061610</ref><ref group="xtra">PMID:009285490</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Triose-phosphate isomerase]]
[[Category: Large Structures]]
[[Category: Hol, W G.J.]]
[[Category: Hol WGJ]]
[[Category: Mande, S C.]]
[[Category: Mande SC]]
Retrieved from "https://proteopedia.org/1hti"