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[[Image:2b35.png|left|200px]]


{{STRUCTURE_2b35|  PDB=2b35  |  SCENE=  }}
==Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan==
 
<StructureSection load='2b35' size='340' side='right'caption='[[2b35]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2b35]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B35 FirstGlance]. <br>
{{ABSTRACT_PUBMED_017163639}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b35 OCA], [https://pdbe.org/2b35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b35 RCSB], [https://www.ebi.ac.uk/pdbsum/2b35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b35 ProSAT]</span></td></tr>
[[2b35]] is a 6 chain structure of [[Enoyl-Acyl-Carrier Protein Reductase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B35 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b35_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b35 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Enoyl-Acyl-Carrier Protein Reductase|Enoyl-Acyl-Carrier Protein Reductase]]
*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:017163639</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Amin, A.]]
[[Category: Amin A]]
[[Category: Boyne, M S.]]
[[Category: Boyne MS]]
[[Category: Johnson, F.]]
[[Category: Johnson F]]
[[Category: Kaur, T.]]
[[Category: Kaur T]]
[[Category: Novichenok, P.]]
[[Category: Novichenok P]]
[[Category: Stratton, C.]]
[[Category: Stratton C]]
[[Category: Sullivan, T J.]]
[[Category: Sullivan TJ]]
[[Category: Truglio, J J.]]
[[Category: Truglio JJ]]
[[Category: Zhang, X.]]
[[Category: Zhang X]]
[[Category: Enoyl reductase]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/2b35"