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[[Image:1jch.png|left|200px]]


{{STRUCTURE_1jch|  PDB=1jch  |  SCENE=  }}
==Crystal Structure of Colicin E3 in Complex with its Immunity Protein==
 
<StructureSection load='1jch' size='340' side='right'caption='[[1jch]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
===Crystal Structure of Colicin E3 in Complex with its Immunity Protein===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1jch]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._W3110 Escherichia coli str. K-12 substr. W3110]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JCH FirstGlance]. <br>
{{ABSTRACT_PUBMED_11741540}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.02&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jch OCA], [https://pdbe.org/1jch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jch RCSB], [https://www.ebi.ac.uk/pdbsum/1jch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jch ProSAT]</span></td></tr>
[[1jch]] is a 4 chain structure of [[Colicin]] and [[Colicin Immunity Protein]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_str._k12_substr. Escherichia coli str. k12 substr.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JCH OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CEA3_ECOLX CEA3_ECOLX] Inactivates ribosomes by hydrolyzing 16S RNA in 30S ribosomes at a specific site.  Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/1jch_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jch ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Colicin|Colicin]]
*[[Colicin 3D structures|Colicin 3D structures]]
*[[Colicin Immunity Protein|Colicin Immunity Protein]]
*[[Colicin immunity protein 3D structures|Colicin immunity protein 3D structures]]
*[[Im3|Im3]]
__TOC__
 
</StructureSection>
==Reference==
[[Category: Escherichia coli str. K-12 substr. W3110]]
<ref group="xtra">PMID:011741540</ref><ref group="xtra">PMID:012555855</ref><ref group="xtra">PMID:014528291</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Escherichia coli str. k12 substr.]]
[[Category: Jakes K]]
[[Category: Jakes, K.]]
[[Category: Li C]]
[[Category: Li, C.]]
[[Category: Shoham M]]
[[Category: Shoham, M.]]
[[Category: Soelaiman S]]
[[Category: Soelaiman, S.]]
[[Category: Wu N]]
[[Category: Wu, N.]]
[[Category: Hydrolase]]
[[Category: Ribosome inhibitor]]
[[Category: The receptor-binding domain is a coiled coil]]
[[Category: The rnase domain is a six-stranded antiparallel beta-sheet. the immunity protein is a four-stranded antiparallel beta sheet flanked by 3 helices on one side of the sheet]]
[[Category: Translocation domain is a beta-jellyroll]]
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