3qea: Difference between revisions
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==Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA (complex II)== | |||
<StructureSection load='3qea' size='340' side='right'caption='[[3qea]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3qea]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QEA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qea OCA], [https://pdbe.org/3qea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qea RCSB], [https://www.ebi.ac.uk/pdbsum/3qea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qea ProSAT]</span></td></tr> | ||
[[3qea]] is a 3 chain structure | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/EXO1_HUMAN EXO1_HUMAN] 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.<ref>PMID:10364235</ref> <ref>PMID:10608837</ref> <ref>PMID:11809771</ref> <ref>PMID:11842105</ref> <ref>PMID:12414623</ref> <ref>PMID:12704184</ref> <ref>PMID:14636568</ref> <ref>PMID:14676842</ref> <ref>PMID:15225546</ref> <ref>PMID:15886194</ref> <ref>PMID:16143102</ref> <ref>PMID:9685493</ref> | |||
==See Also== | ==See Also== | ||
*[[Exonuclease|Exonuclease]] | *[[Exonuclease 3D structures|Exonuclease 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Beese | [[Category: Large Structures]] | ||
[[Category: Hast | [[Category: Beese LS]] | ||
[[Category: Hellinga | [[Category: Hast MA]] | ||
[[Category: Iyer | [[Category: Hellinga HW]] | ||
[[Category: McSweeney | [[Category: Iyer RR]] | ||
[[Category: Modrich | [[Category: McSweeney EA]] | ||
[[Category: Orans | [[Category: Modrich P]] | ||
[[Category: Orans J]] | |||
Latest revision as of 10:47, 21 February 2024
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA (complex II)
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