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[[Image:1w37.png|left|200px]]


{{STRUCTURE_1w37|  PDB=1w37  |  SCENE=  }}
==2-keto-3-deoxygluconate(KDG) aldolase of Sulfolobus solfataricus==
 
<StructureSection load='1w37' size='340' side='right'caption='[[1w37]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===2-KETO-3-DEOXYGLUCONATE(KDG) ALDOLASE OF SULFOLOBUS SOLFATARICUS===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1w37]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W37 FirstGlance]. <br>
{{ABSTRACT_PUBMED_15265860}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w37 OCA], [https://pdbe.org/1w37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w37 RCSB], [https://www.ebi.ac.uk/pdbsum/1w37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w37 ProSAT]</span></td></tr>
[[1w37]] is a 4 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W37 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDGA_SACSO KDGA_SACSO] Involved in the degradation of glucose and galactose via the Entner-Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is also able to catalyze the reversible cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal). It is equally active with both D- and L-glyceraldehyde.<ref>PMID:10527934</ref> <ref>PMID:12824170</ref> <ref>PMID:16330030</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/1w37_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w37 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldolase|Aldolase]]
*[[Aldolase 3D structures|Aldolase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:015265860</ref><references group="xtra"/>
__TOC__
[[Category: 2-dehydro-3-deoxyglucarate aldolase]]
</StructureSection>
[[Category: Sulfolobus solfataricus]]
[[Category: Large Structures]]
[[Category: Connaris, H.]]
[[Category: Saccharolobus solfataricus]]
[[Category: Danson, M J.]]
[[Category: Connaris H]]
[[Category: Hough, D W.]]
[[Category: Danson MJ]]
[[Category: Lamble, H J.]]
[[Category: Hough DW]]
[[Category: Taylor, G L.]]
[[Category: Lamble HJ]]
[[Category: Theodossis, A.]]
[[Category: Taylor GL]]
[[Category: Walden, H.]]
[[Category: Theodossis A]]
[[Category: Westwick, E J.]]
[[Category: Walden H]]
[[Category: Aldolase]]
[[Category: Westwick EJ]]
[[Category: Archaeal metabolism]]
[[Category: Thermostability]]
Retrieved from "https://proteopedia.org/1w37"