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[[Image:3lsv.png|left|200px]]


{{STRUCTURE_3lsv|  PDB=3lsv  |  SCENE=  }}
==Structure of the A237F mutant of the pentameric ligand gated ion channel from Gloeobacter Violaceus==
 
<StructureSection load='3lsv' size='340' side='right'caption='[[3lsv]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
===Structure of the A237F mutant of the pentameric ligand gated ion channel from Gloeobacter Violaceus===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3lsv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LSV FirstGlance]. <br>
{{ABSTRACT_PUBMED_20308576}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lsv OCA], [https://pdbe.org/3lsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lsv RCSB], [https://www.ebi.ac.uk/pdbsum/3lsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lsv ProSAT]</span></td></tr>
==About this Structure==
</table>
[[3lsv]] is a 5 chain structure of [[]] and [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LSV OCA].  
== Function ==
[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ls/3lsv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lsv ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[|]]
*[[Ion channels 3D structures|Ion channels 3D structures]]
*[[Ion channels|Ion channels]]
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:020308576</ref><references group="xtra"/>
</StructureSection>
[[Category: Gloeobacter violaceus]]
[[Category: Gloeobacter violaceus]]
[[Category: Corringer, P J.]]
[[Category: Large Structures]]
[[Category: Delarue, M.]]
[[Category: Corringer PJ]]
[[Category: Nury, H.]]
[[Category: Delarue M]]
[[Category: Channel]]
[[Category: Nury H]]
[[Category: Cys-loop]]
[[Category: Membrane protein]]
[[Category: Plgic]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/3lsv"