2lwk: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 2lwk is ON HOLD Authors: Lee, M.-K., Varani, G., Choi, B.-S., Pellecchia, M. Description: Solution structure of small molecule-influenza RNA comple... |
No edit summary |
||
| (10 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
The | ==Solution structure of small molecule-influenza RNA complex== | ||
<StructureSection load='2lwk' size='340' side='right'caption='[[2lwk]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2lwk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0EC:6,7-DIMETHOXY-2-(PIPERAZIN-1-YL)QUINAZOLIN-4-AMINE'>0EC</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwk OCA], [https://pdbe.org/2lwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwk RCSB], [https://www.ebi.ac.uk/pdbsum/2lwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwk ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses. | |||
A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.,Lee MK, Bottini A, Kim M, Bardaro MF Jr, Zhang Z, Pellecchia M, Choi BS, Varani G Chem Commun (Camb). 2014 Jan 11;50(3):368-70. doi: 10.1039/c3cc46973e. Epub 2013 , Nov 18. PMID:24247110<ref>PMID:24247110</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2lwk" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Choi B-S]] | |||
[[Category: Lee M-K]] | |||
[[Category: Pellecchia M]] | |||
[[Category: Varani G]] | |||
Latest revision as of 05:54, 15 May 2024
Solution structure of small molecule-influenza RNA complex
| ||||||||||||
