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'''Unreleased structure'''


The entry 4gdy is ON HOLD
==Kynurenine Aminotransferase II inhibitors==
 
<StructureSection load='4gdy' size='340' side='right'caption='[[4gdy]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
Authors: Pandit, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4gdy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GDY FirstGlance]. <br>
Description: Kynurenine Aminotransferase II inhibitors
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0X1:(5-HYDROXY-6-METHYL-4-{[(1-OXO-7-PHENOXY-1,2-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-4-YL)AMINO]METHYL}PYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>0X1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gdy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gdy OCA], [https://pdbe.org/4gdy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gdy RCSB], [https://www.ebi.ac.uk/pdbsum/4gdy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gdy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Pandit J]]
Retrieved from "https://proteopedia.org/4gdy"