4ge4: Difference between revisions

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'''Unreleased structure'''


The entry 4ge4 is ON HOLD
==Kynurenine Aminotransferase II Inhibitors==
 
<StructureSection load='4ge4' size='340' side='right'caption='[[4ge4]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
Authors: Pandit, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ge4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GE4 FirstGlance]. <br>
Description: Kynurenine Aminotransferase II Inhibitors
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KE:(5-HYDROXY-4-{[(1-HYDROXY-7-METHOXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>0KE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ge4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ge4 OCA], [https://pdbe.org/4ge4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ge4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ge4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ge4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Pandit J]]
Retrieved from "https://proteopedia.org/4ge4"