3uxm: Difference between revisions

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[[Image:3uxm.png|left|200px]]


{{STRUCTURE_3uxm| PDB=3uxm | SCENE= }}
==Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation==
<StructureSection load='3uxm' size='340' side='right'caption='[[3uxm]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uxm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UXM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DN:5-DEOXY-5-FLUOROTHYMIDINE'>0DN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uxm OCA], [https://pdbe.org/3uxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uxm RCSB], [https://www.ebi.ac.uk/pdbsum/3uxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uxm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).


===Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation===
==See Also==
 
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
{{ABSTRACT_PUBMED_22243413}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3uxm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXM OCA].
[[Category: Pseudomonas aeruginosa PAO1]]
 
[[Category: Chang J]]
==Reference==
[[Category: Choi JY]]
<ref group="xtra">PMID:022243413</ref><references group="xtra"/>
[[Category: Desbonnet CR]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Dillman K]]
[[Category: DTMP kinase]]
[[Category: Miller AA]]
[[Category: Chang, J.]]
[[Category: Miller JR]]
[[Category: Choi, J Y.]]
[[Category: Plummer MS]]
[[Category: Desbonnet, C R.]]
[[Category: Roush WR]]
[[Category: Dillman, K.]]
[[Category: Soutter HH]]
[[Category: Miller, A A.]]
[[Category: Starr J]]
[[Category: Miller, J R.]]
[[Category: Plummer, M S.]]
[[Category: Roush, W R.]]
[[Category: Soutter, H H.]]
[[Category: Starr, J.]]
[[Category: Thymidine triphosphate]]
[[Category: Thymidylate kinase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/3uxm"