3ue8: Difference between revisions

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[[Image:3ue8.png|left|200px]]


{{STRUCTURE_3ue8|  PDB=3ue8  |  SCENE=  }}
==Kynurenine Aminotransferase II Inhibitors==
 
<StructureSection load='3ue8' size='340' side='right'caption='[[3ue8]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
===Kynurenine Aminotransferase II Inhibitors===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3ue8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UE8 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.22&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=09M:(5-HYDROXY-4-{[(1-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>09M</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
[[3ue8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ue8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue8 OCA], [https://pdbe.org/3ue8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ue8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ue8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ue8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Anderson, M.]]
[[Category: Large Structures]]
[[Category: Bechle, B M.]]
[[Category: Anderson M]]
[[Category: Campbell, B M.]]
[[Category: Bechle BM]]
[[Category: Claffey, M M.]]
[[Category: Campbell BM]]
[[Category: Dounay, A B.]]
[[Category: Claffey MM]]
[[Category: Edelweiss, E.]]
[[Category: Dounay AB]]
[[Category: Evdokimov, A.]]
[[Category: Edelweiss E]]
[[Category: Fonseca, K R.]]
[[Category: Evdokimov A]]
[[Category: Gan, X.]]
[[Category: Fonseca KR]]
[[Category: Ghosh, S.]]
[[Category: Gan X]]
[[Category: Hayward, M M.]]
[[Category: Ghosh S]]
[[Category: Horner, W.]]
[[Category: Hayward MM]]
[[Category: Kim, J Y.]]
[[Category: Horner W]]
[[Category: McAllister, L A.]]
[[Category: Kim JY]]
[[Category: Pandit, J.]]
[[Category: McAllister LA]]
[[Category: Paradis, V.]]
[[Category: Pandit J]]
[[Category: Parikh, V D.]]
[[Category: Paradis V]]
[[Category: Reese, M R.]]
[[Category: Parikh VD]]
[[Category: Rong, S B.]]
[[Category: Reese MR]]
[[Category: Salafia, M A.]]
[[Category: Rong SB]]
[[Category: Schuyten, K.]]
[[Category: Salafia MA]]
[[Category: Strick, C A.]]
[[Category: Schuyten K]]
[[Category: Tuttle, J B.]]
[[Category: Strick CA]]
[[Category: Valentine, J.]]
[[Category: Tuttle JB]]
[[Category: Verhoest, P R.]]
[[Category: Valentine J]]
[[Category: Wang, H.]]
[[Category: Verhoest PR]]
[[Category: Zawadzke, L E.]]
[[Category: Wang H]]
[[Category: Kat ii]]
[[Category: Zawadzke LE]]
[[Category: Kynurenine aminotransferase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/3ue8"