2jp6: Difference between revisions
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==Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32== | |||
<StructureSection load='2jp6' size='340' side='right'caption='[[2jp6]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2jp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tityus_obscurus Tityus obscurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JP6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 25 models</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jp6 OCA], [https://pdbe.org/2jp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jp6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jp6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KA181_TITOB KA181_TITOB] Reversible blocker of both Kv1.3/KCNA3 potassium channels (high affinity) and Shaker B (mammalian Kv1.1 analog) potassium channels (very low affinity).<ref>PMID:12445473</ref> | |||
=== | ==See Also== | ||
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]] | |||
== References == | |||
<references/> | |||
[[ | __TOC__ | ||
[[Category: Tityus | </StructureSection> | ||
[[Category: Belluzzi | [[Category: Large Structures]] | ||
[[Category: Pertinhez | [[Category: Tityus obscurus]] | ||
[[Category: Pignatelli | [[Category: Belluzzi O]] | ||
[[Category: Sforca | [[Category: Pertinhez TA]] | ||
[[Category: Spisni | [[Category: Pignatelli A]] | ||
[[Category: Stehling | [[Category: Sforca ML]] | ||
[[Category: Zanchin | [[Category: Spisni A]] | ||
[[Category: Stehling EG]] | |||
[[Category: Zanchin NI]] | |||
Latest revision as of 09:13, 6 November 2024
Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32
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