2gku: Difference between revisions

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[[Image:2gku.png|left|200px]]


{{STRUCTURE_2gku| PDB=2gku |  SCENE= }}
==Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures==
<StructureSection load='2gku' size='340' side='right'caption='[[2gku]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2gku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GKU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gku OCA], [https://pdbe.org/2gku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gku RCSB], [https://www.ebi.ac.uk/pdbsum/2gku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gku ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.


===Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures===
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.,Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556<ref>PMID:16866556</ref>


{{ABSTRACT_PUBMED_16866556}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 2gku" style="background-color:#fffaf0;"></div>
[[2gku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:016866556</ref><references group="xtra"/>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kuryavyi, V V.]]
[[Category: Large Structures]]
[[Category: Lacroix, L.]]
[[Category: Kuryavyi VV]]
[[Category: Luu, K N.]]
[[Category: Lacroix L]]
[[Category: Patel, D J.]]
[[Category: Luu KN]]
[[Category: Phan, A T.]]
[[Category: Patel DJ]]
[[Category: 12 structure]]
[[Category: Phan AT]]
[[Category: 3+1 strand folding]]
[[Category: Dna]]
[[Category: Double-chain reversal loop]]
[[Category: Edgewise]]
[[Category: G-tetrad]]
[[Category: Nmr]]
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