3ozr: Difference between revisions

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[[Image:3ozr.png|left|200px]]


{{STRUCTURE_3ozr| PDB=3ozr | SCENE= }}
==Rat catechol O-methyltransferase in complex with a catechol-type, bisubstrate inhibitor, no substituent in the adenine site - humanized form==
<StructureSection load='3ozr' size='340' side='right'caption='[[3ozr]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ozr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OZR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OZR:N-[(E)-3-[(2R,3S,4S)-3,4-DIHYDROXYOXOLAN-2-YL]PROP-2-ENYL]-2,3-DIHYDROXY-5-NITRO-BENZAMIDE'>OZR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ozr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ozr OCA], [https://pdbe.org/3ozr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ozr RCSB], [https://www.ebi.ac.uk/pdbsum/3ozr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ozr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.


===Rat catechol O-methyltransferase in complex with a catechol-type, bisubstrate inhibitor, no substituent in the adenine site - humanized form===
==See Also==
 
*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
{{ABSTRACT_PUBMED_21538606}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3ozr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZR OCA].
 
==Reference==
<ref group="xtra">PMID:021538606</ref><references group="xtra"/>
[[Category: Catechol O-methyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Benz, J.]]
[[Category: Benz J]]
[[Category: Ehler, A.]]
[[Category: Ehler A]]
[[Category: Rudolph, M G.]]
[[Category: Rudolph MG]]
[[Category: Schlatter, D.]]
[[Category: Schlatter D]]
[[Category: Stihle, M.]]
[[Category: Stihle M]]
[[Category: Alternative initiation]]
[[Category: Catecholamine metabolism]]
[[Category: Cell membrane]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Methyltransferase]]
[[Category: Neurotransmitter degradation]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Signal-anchor]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Transmembrane methyltransferase]]
Retrieved from "https://proteopedia.org/3ozr"