4gfn: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4gfn is ~~ON HOLD~~

==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic==

== Structural highlights ==

<table><tr><td colspan='2'>[[4gfn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFN OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4GFN FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SUY:(1R,5S,6S)-3-[5-CHLORO-6-ETHYL-2-(PYRIMIDIN-5-YLSULFANYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL]-3-AZABICYCLO[3.1.0]HEXAN-6-AMINE'>SUY</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4gfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gfn OCA], [https://pdbe.org/4gfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gfn RCSB], [https://www.ebi.ac.uk/pdbsum/4gfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gfn ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/GYRB_ENTFA GYRB_ENTFA]

~~Authors~~: Bensen~~, D.C., Trzoss, M.,~~ Tari~~, L.W.~~

==See Also==

*[[Gyrase 3D Structures|Gyrase 3D Structures]]

~~Description~~: ~~PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC ACTIVITY.~~

__TOC__

</StructureSection>

[[Category: Enterococcus faecalis V583]]

[[Category: Large Structures]]

[[Category: Bensen DC]]

[[Category: Tari LW]]

[[Category: Trzoss M]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4gfn is ON HOLD
+==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic==
+<StructureSection load='4gfn' size='340' side='right'caption='[[4gfn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4gfn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GFN FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SUY:(1R,5S,6S)-3-[5-CHLORO-6-ETHYL-2-(PYRIMIDIN-5-YLSULFANYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL]-3-AZABICYCLO[3.1.0]HEXAN-6-AMINE'>SUY</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gfn OCA], [https://pdbe.org/4gfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gfn RCSB], [https://www.ebi.ac.uk/pdbsum/4gfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gfn ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GYRB_ENTFA GYRB_ENTFA]
-Authors: Bensen, D.C., Trzoss, M., Tari, L.W.
+==See Also==
+*[[Gyrase 3D Structures|Gyrase 3D Structures]]
-Description: PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC ACTIVITY.
+__TOC__
+</StructureSection>
+[[Category: Enterococcus faecalis V583]]
+[[Category: Large Structures]]
+[[Category: Bensen DC]]
+[[Category: Tari LW]]
+[[Category: Trzoss M]]