4frf: Difference between revisions
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==Structural Studies and Protein Engineering of Inositol Phosphate Multikinase== | |||
<StructureSection load='4frf' size='340' side='right'caption='[[4frf]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4frf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FRF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[4frf]] is a 2 chain structure with sequence from [ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4frf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frf OCA], [https://pdbe.org/4frf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4frf RCSB], [https://www.ebi.ac.uk/pdbsum/4frf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4frf ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IPMKA_ARATH IPMKA_ARATH] Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) and inositol 1,2,3,4,6-pentakisphosphate (Ins(1,2,3,4,6)P5) but not inositol 1,4-bisphosphate (Ins(1,4)P2), inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), inositol 1,2,6-trisphosphate (Ins(1,2,6)P3), inositol 3,4,5,6-tetrakisphosphate (Ins(3,4,5,6)P4), inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5), inositol 1,2,4,5,6-pentakisphosphate (Ins(1,2,4,5,6)P5) or inositol hexakisphosphate (InsP6). Regulates pollen and root development probably through the regulation of InsP3-mediated calcium accumulation.<ref>PMID:12226109</ref> <ref>PMID:15618435</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
[[Category: Endo-Streeter | [[Category: Large Structures]] | ||
[[Category: Odom | [[Category: Endo-Streeter ST]] | ||
[[Category: Tsui | [[Category: Odom AR]] | ||
[[Category: York | [[Category: Tsui M]] | ||
[[Category: York JD]] | |||
Latest revision as of 11:23, 1 March 2024
Structural Studies and Protein Engineering of Inositol Phosphate Multikinase
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