SAM-dependent methyltransferase: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Michal Harel (talk | contribs)
32,831 edits
No edit summary
Michal Harel (talk | contribs)
32,831 edits
No edit summary
 
(26 intermediate revisions by 3 users not shown)
Line 1: Line 1:
{{STRUCTURE_3h2b|  PDB=3h2b  | SIZE=400| SCENE= |right|CAPTION=SAM-dependent methyltransferase complex with S-adenosyl-L-homocysteine and pyrophosphate, [[3h2b]] }}
<StructureSection load='' size='350' side='right' scene='51/510230/Cv/3' caption='SAM-dependent methyltransferase dimer complex with S-adenosyl-L-homocysteine and sulfate [[3ou6]]'>
   
== Function ==   
'''SAM-dependent methyltransferase''' (SDM) utilizes the methyl donor S-adenosyl-L-methionine (SAM) as a cofactor to methylate proteins, small molecules, lipids and nucleic acids.  SAM forms S-adenosyl-L-homocysteine (SAH) upon demethylation.  About 120 members of the SDM family have been identified.  They differ in their substrate specificity and the atom targeted for methylation (N, O, C, S). The core of the SDM fold contains alternating β strands and α helices.
'''SAM-dependent methyltransferase''' or '''S-adenosylmethionine-dependent methyltransferase''' (SDM) utilizes the methyl donor S-adenosyl-L-methionine (SAM) as a cofactor to methylate proteins, small molecules, lipids and nucleic acids.  SAM forms S-adenosyl-L-homocysteine (SAH) upon demethylation.  About 120 members of the SDM family have been identified.  They differ in their substrate specificity and the atom targeted for methylation ('''N, O, C, S''')<ref>PMID:23180741</ref>.  
For '''Chemotaxis receptor methyltransferase CheR''' see details in [[Molecular Playground/CheR]].<ref>PMID:9628482</ref>.<br />
*SEE ALSO [[Chemotaxis protein]].
 
== Structural highlights ==
The <scene name='51/510230/Cv/5'>core of the SDM fold contains alternating β strands and α helices</scene>.  SDM <scene name='51/510230/Cv/6'>active site is located between the 2 monomers</scene><ref>PMID:20876132</ref>. Water molecules are shown as red spheres.  


==3D structures of SAM-dependent methyltrasferase==
==3D structures of SAM-dependent methyltrasferase==
[[SAM-dependent methyltrasferase 3D structures]]


===SAM-dependent O-methyltransferase===
</StructureSection>
 
[[1o54]] – TmSDM – ''Thermotoga maritima''<br />
[[2hnk]] – SDM – ''Leptospira interrogans''<br />
[[3r3h]] – SDM – ''Legionella pneumophila''
 
===SAM-dependent N-methyltransferase===
 
[[1vlm]] – TmSDM (mutant)
 
===SAM-dependent methyltransferase===


[[1wzn]] – SDM – ''Pyrococcus horikoshii''<br />
== References ==
[[2igt]] – SDM –'' Agrobacterium tumefaciens''<br />
<references/>
[[3cgg]] – CgSDM – ''Corynebacterium glutamicum''<br />
[[Category:Topic Page]]
[[3d2l]] - SDM – ''Exiguobacterium sibiricum''<br />
[[3dh0]] - SDM – ''Aquifex aeolicus''<br />
[[3dp7]] - SDM – ''Bacterioides vulgatus''<br />
[[3ggd]] - SDM – ''Anabaena variabilis''<br />
[[3sm3]] - SDM (mutant) – ''Methanosarcina mazei''<br />
[[3h2b]] – CgSDM + pyrophosphate + SAH

Latest revision as of 09:25, 11 August 2024

SAM-dependent methyltransferase dimer complex with S-adenosyl-L-homocysteine and sulfate 3ou6

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "https://proteopedia.org/index.php?title=SAM-dependent_methyltransferase&oldid=4200132"