4gle: Difference between revisions
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New page: '''Unreleased structure''' The entry 4gle is ON HOLD Authors: Meulenbroek, E.M., Peron Cane, C. , Jala, I., Iwai, S., Moolenaar, G.F., Goosen, N., Pannu, N.S. Description: SacUVDE in c... |
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==SacUVDE in complex with 6-4PP-containing DNA== | |||
<StructureSection load='4gle' size='340' side='right'caption='[[4gle]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4gle]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5PY:1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-5-METHYLPYRIMIDIN-2(1H)-ONE'>5PY</scene>, <scene name='pdbligand=64T:5-HYDROXY-THYMIDINE-5-MONOPHOSPHATE'>64T</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gle OCA], [https://pdbe.org/4gle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gle RCSB], [https://www.ebi.ac.uk/pdbsum/4gle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gle ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q4J9T1_SULAC Q4J9T1_SULAC] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Repairing damaged DNA is essential for an organism's survival. UV damage endonuclease (UVDE) is a DNA-repair enzyme that can recognize and incise different types of damaged DNA. We present the structure of Sulfolobus acidocaldarius UVDE on its own and in a pre-catalytic complex with UV-damaged DNA containing a 6-4 photoproduct showing a novel 'dual dinucleotide flip' mechanism for recognition of damaged dipyrimidines: the two purines opposite to the damaged pyrimidine bases are flipped into a dipurine-specific pocket, while the damaged bases are also flipped into another cleft. | |||
UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions.,Meulenbroek EM, Peron Cane C, Jala I, Iwai S, Moolenaar GF, Goosen N, Pannu NS Nucleic Acids Res. 2012 Dec 11. PMID:23221644<ref>PMID:23221644</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4gle" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Endonuclease 3D structures|Endonuclease 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Sulfolobus acidocaldarius]] | |||
[[Category: Goosen N]] | |||
[[Category: Iwai S]] | |||
[[Category: Jala I]] | |||
[[Category: Meulenbroek EM]] | |||
[[Category: Moolenaar GF]] | |||
[[Category: Pannu NS]] | |||
[[Category: Peron Cane C]] | |||
Latest revision as of 10:54, 6 November 2024
SacUVDE in complex with 6-4PP-containing DNA
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