4b7w: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4b7w is ~~ON HOLD~~

==Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form==

~~Authors~~: ~~Dudasova~~, Z., ~~Okvist~~, M., ~~Kretova~~, M., ~~Ondrovicova~~, G., ~~Skrabana~~, R., LeGuevel, R~~., Salbert, G.,~~ Leonard, G., McSweeney, S~~., Barath, P.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4b7w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7W FirstGlance]. <br>

~~Description~~: ~~Ligand binding domain human hepatocyte nuclear factor 4alpha~~: ~~Apo form~~

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4Å</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7w OCA], [https://pdbe.org/4b7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7w RCSB], [https://www.ebi.ac.uk/pdbsum/4b7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7w ProSAT]</span></td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN] Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) [MIM:[https://omim.org/entry/125850 125850]; also symbolized MODY-1. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:9313765</ref> <ref>PMID:9243109</ref> <ref>PMID:9449683</ref>

== Function ==

[https://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN] Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Barath P]]

[[Category: Dudasova Z]]

[[Category: Kretova M]]

[[Category: LeGuevel R]]

[[Category: Leonard G]]

[[Category: McSweeney S]]

[[Category: Okvist M]]

[[Category: Ondrovicova G]]

[[Category: Salbert G]]

[[Category: Skrabana R]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4b7w is ON HOLD
+==Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form==
+<StructureSection load='4b7w' size='340' side='right'caption='[[4b7w]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
-Authors: Dudasova, Z., Okvist, M., Kretova, M., Ondrovicova, G., Skrabana, R., LeGuevel, R., Salbert, G., Leonard, G., McSweeney, S., Barath, P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4b7w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7W FirstGlance]. <br>
-Description: Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7w OCA], [https://pdbe.org/4b7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7w RCSB], [https://www.ebi.ac.uk/pdbsum/4b7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7w ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN] Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) [MIM:[https://omim.org/entry/125850 125850]; also symbolized MODY-1. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:9313765</ref> <ref>PMID:9243109</ref> <ref>PMID:9449683</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN] Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Barath P]]
+[[Category: Dudasova Z]]
+[[Category: Kretova M]]
+[[Category: LeGuevel R]]
+[[Category: Leonard G]]
+[[Category: McSweeney S]]
+[[Category: Okvist M]]
+[[Category: Ondrovicova G]]
+[[Category: Salbert G]]
+[[Category: Skrabana R]]