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[[Image:2jkc.png|left|200px]]


{{STRUCTURE_2jkc|  PDB=2jkc  |  SCENE=  }}
==Crystal Structure of E346D of Tryptophan 7-Halogenase (PrnA)==
 
<StructureSection load='2jkc' size='340' side='right'caption='[[2jkc]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal Structure of E346D of Tryptophan 7-Halogenase (PrnA)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2jkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JKC FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
[[2jkc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKC OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkc OCA], [https://pdbe.org/2jkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jkc RCSB], [https://www.ebi.ac.uk/pdbsum/2jkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jkc ProSAT]</span></td></tr>
 
</table>
==Reference==
== Function ==
<ref group="xtra">PMID:018979475</ref><ref group="xtra">PMID:016195462</ref><references group="xtra"/>
[https://www.uniprot.org/uniprot/PRNA_PSEFL PRNA_PSEFL] Involved in the biosynthesis of the antifungal antibiotic pyrrolnitrin. Catalyze the chlorination of tryptophan (Trp) at C7 position to yield 7-chloro-L-tryptophan (7-CLT). The reaction between FADH2, Cl-, and O2 generates the powerful oxidant HOCl, which is presumed to carry out the chlorination reaction. The reaction of HOCl with the active site Lys-79 generates a lysine chloramine, which plays a key role in directing regiospecific chlorination of substrate in this important class of biosynthetic enzymes. It is also able to use bromide ions to generate monobrominated Trp.<ref>PMID:10941070</ref> <ref>PMID:9172332</ref> <ref>PMID:9537395</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jkc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jkc ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas fluorescens]]
[[Category: Pseudomonas fluorescens]]
[[Category: Naismith, J H.]]
[[Category: Naismith JH]]
[[Category: Zhu, X.]]
[[Category: Zhu X]]
[[Category: Enzymatic halogenation]]
[[Category: Flavin- dependent reaction mechanism]]
[[Category: Oxidoreductase]]
[[Category: Tryptophan halogenase]]
Retrieved from "https://proteopedia.org/2jkc"