4gah: Difference between revisions

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[[Image:4gah.jpg|left|200px]]


{{STRUCTURE_4gah|  PDB=4gah  |  SCENE=  }}
==Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor==
 
<StructureSection load='4gah' size='340' side='right'caption='[[4gah]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4gah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAH FirstGlance]. <br>
{{ABSTRACT_PUBMED_22871024}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0ET:[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(3R)-2,2-DIMETHYL-3-OXIDANYL-4-OXIDANYLIDENE-4-[[3-OXIDANYLIDENE-3-[2-[(2R)-2-OXIDANYLUNDECYL]SULFANYLETHYLAMINO]PROPYL]AMINO]BUTYL]+HYDROGEN+PHOSPHATE'>0ET</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gah OCA], [https://pdbe.org/4gah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gah RCSB], [https://www.ebi.ac.uk/pdbsum/4gah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gah ProSAT]</span></td></tr>
[[4gah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAH OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/THEM4_HUMAN THEM4_HUMAN] Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.<ref>PMID:11598301</ref> <ref>PMID:17615157</ref> <ref>PMID:19453107</ref> <ref>PMID:19168129</ref> <ref>PMID:19421406</ref> <ref>PMID:22871024</ref>
<ref group="xtra">PMID:022871024</ref><references group="xtra"/>
== References ==
[[Category: Acyl-CoA hydrolase]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Herzberg, O.]]
[[Category: Large Structures]]
[[Category: Lim, K.]]
[[Category: Herzberg O]]
[[Category: Pathak, M C.]]
[[Category: Lim K]]
[[Category: Acyl coa hydrolase]]
[[Category: Pathak MC]]
[[Category: Acyl-coa]]
[[Category: Akt c-terminal modulating protein]]
[[Category: Hotdog fold]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
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