2lwk: Difference between revisions

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[[Image:2lwk.jpg|left|200px]]


{{STRUCTURE_2lwk| PDB=2lwk |  SCENE= }}
==Solution structure of small molecule-influenza RNA complex==
<StructureSection load='2lwk' size='340' side='right'caption='[[2lwk]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lwk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0EC:6,7-DIMETHOXY-2-(PIPERAZIN-1-YL)QUINAZOLIN-4-AMINE'>0EC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwk OCA], [https://pdbe.org/2lwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwk RCSB], [https://www.ebi.ac.uk/pdbsum/2lwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwk ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.


===Solution structure of small molecule-influenza RNA complex===
A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.,Lee MK, Bottini A, Kim M, Bardaro MF Jr, Zhang Z, Pellecchia M, Choi BS, Varani G Chem Commun (Camb). 2014 Jan 11;50(3):368-70. doi: 10.1039/c3cc46973e. Epub 2013 , Nov 18. PMID:24247110<ref>PMID:24247110</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
[[2lwk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWK OCA].
<div class="pdbe-citations 2lwk" style="background-color:#fffaf0;"></div>
[[Category: Choi, B S.]]
== References ==
[[Category: Lee, M K.]]
<references/>
[[Category: Pellecchia, M.]]
__TOC__
[[Category: Varani, G.]]
</StructureSection>
[[Category: Double helix]]
[[Category: Large Structures]]
[[Category: Rna]]
[[Category: Choi B-S]]
[[Category: Lee M-K]]
[[Category: Pellecchia M]]
[[Category: Varani G]]
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