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[[Image:4asi.jpg|left|200px]]


{{STRUCTURE_4asi| PDB=4asi | SCENE= }}
==Crystal structure of human ACACA C-terminal domain==
<StructureSection load='4asi' size='340' side='right'caption='[[4asi]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4asi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asi OCA], [https://pdbe.org/4asi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asi RCSB], [https://www.ebi.ac.uk/pdbsum/4asi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asi ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[https://omim.org/entry/613933 613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref>
== Function ==
[https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref>


===Crystal structure of human ACACA C-terminal domain===
==See Also==
 
*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[4asi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASI OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Delft, F Von.]]
[[Category: Bountra C]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Froese, D S.]]
[[Category: Froese DS]]
[[Category: Kiyani, W.]]
[[Category: Kiyani W]]
[[Category: Krojer, T.]]
[[Category: Krojer T]]
[[Category: Muniz, J R.C.]]
[[Category: Muniz JRC]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Vollmar, M.]]
[[Category: Vollmar M]]
[[Category: Yue, W W.]]
[[Category: Yue WW]]
[[Category: Ligase]]
[[Category: Von Delft F]]
[[Category: Protein]]
Retrieved from "https://proteopedia.org/4asi"