4e15: Difference between revisions
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==Crystal structure of kynurenine formamidase conjugated with an inhibitor== | |||
<StructureSection load='4e15' size='340' side='right'caption='[[4e15]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4e15]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E15 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SEB:O-BENZYLSULFONYL-SERINE'>SEB</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e15 OCA], [https://pdbe.org/4e15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e15 RCSB], [https://www.ebi.ac.uk/pdbsum/4e15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e15 ProSAT]</span></td></tr> | ||
[[4e15]] is a 2 chain structure with sequence from [ | </table> | ||
== Function == | |||
== | [https://www.uniprot.org/uniprot/KFA_DROME KFA_DROME] Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites.[HAMAP-Rule:MF_03014]<ref>PMID:22690733</ref> <ref>PMID:83140</ref> | ||
< | == References == | ||
[[ | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Han Q]] | ||
[[Category: | [[Category: Li J]] | ||
[[Category: | [[Category: Robinson H]] | ||
Latest revision as of 14:49, 14 March 2024
Crystal structure of kynurenine formamidase conjugated with an inhibitor
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