4gsf: Difference between revisions

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~~'''Unreleased structure'''~~

The ~~entry~~ 4gsf is ~~ON HOLD~~

==The structure analysis of cysteine free insulin degrading enzyme (ide) with (s)-2-{2-[carboxymethyl-(3-phenyl-propionyl)-amino]-acetylamino}-3-(3h-imidazol-4-yl)-propionic acid methyl ester==

== Structural highlights ==

<table><tr><td colspan='2'>[[4gsf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSF OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4GSF FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGH:METHYL+N-(CARBOXYMETHYL)-N-(3-PHENYLPROPANOYL)GLYCYL-D-HISTIDINATE'>MGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4gsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsf OCA], [https://pdbe.org/4gsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsf RCSB], [https://www.ebi.ac.uk/pdbsum/4gsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsf ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>

~~Authors~~: ~~Guo, Q., Tang, W.J.~~

==See Also==

*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]

~~Description~~: ~~THE STRUCTURE ANALYSIS OF CYSTEINE FREE INSULIN DEGRADING ENZYME (IDE) WITH (S)-2-{2~~-[~~CARBOXYMETHYL-(3-PHENYL-PROPIONYL)-AMINO~~]~~-ACETYLAMINO}-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER~~

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Deprez B]]

[[Category: Deprez-Poulain R]]

[[Category: Guo Q]]

[[Category: Tang WJ]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4gsf is ON HOLD
+==The structure analysis of cysteine free insulin degrading enzyme (ide) with (s)-2-{2-[carboxymethyl-(3-phenyl-propionyl)-amino]-acetylamino}-3-(3h-imidazol-4-yl)-propionic acid methyl ester==
+<StructureSection load='4gsf' size='340' side='right'caption='[[4gsf]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4gsf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSF FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGH:METHYL+N-(CARBOXYMETHYL)-N-(3-PHENYLPROPANOYL)GLYCYL-D-HISTIDINATE'>MGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsf OCA], [https://pdbe.org/4gsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsf RCSB], [https://www.ebi.ac.uk/pdbsum/4gsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
-Authors: Guo, Q., Tang, W.J.
+==See Also==
+*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
-Description: THE STRUCTURE ANALYSIS OF CYSTEINE FREE INSULIN DEGRADING ENZYME (IDE) WITH (S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPIONYL)-AMINO]-ACETYLAMINO}-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Deprez B]]
+[[Category: Deprez-Poulain R]]
+[[Category: Guo Q]]
+[[Category: Tang WJ]]