3u2o: Difference between revisions
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==Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor== | |||
<StructureSection load='3u2o' size='340' side='right'caption='[[3u2o]], [[Resolution|resolution]] 2.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3u2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U2O FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03U:METHYL+4-{[(2Z)-2-CYANO-3-HYDROXYPENT-2-ENOYL]AMINO}-4-FLUOROBIPHENYL-2-CARBOXYLATE'>03U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2o OCA], [https://pdbe.org/3u2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u2o RCSB], [https://www.ebi.ac.uk/pdbsum/3u2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2o ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |||
== | ==See Also== | ||
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]] | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Blaesse | [[Category: Large Structures]] | ||
[[Category: Erra | [[Category: Blaesse M]] | ||
[[Category: Jestel | [[Category: Erra M]] | ||
[[Category: Krapp | [[Category: Jestel A]] | ||
[[Category: Lozoya | [[Category: Krapp S]] | ||
[[Category: Segarra | [[Category: Lozoya E]] | ||
[[Category: Wenzkowski | [[Category: Segarra V]] | ||
[[Category: Wenzkowski C]] | |||
Latest revision as of 13:46, 14 March 2024
Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor
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