Nuclear receptor: Difference between revisions

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New page: == Nuclear Receptor == === Structure === ==== DBD (DNA Binding Domain) ==== ==== LBD (Ligand Binding Domain) ==== <StructureSection load='1ie8' size='350' side='right' caption='Structure ...
 
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== Nuclear Receptor ==
''the nuclear receptors facts book''
<ref>Vincent Laudet, Hinrich Gronemeyer,
"The nuclear receptor factsbook",
Publisher Academic Press, 2002
</ref>


=== Structure ===
SEE [[Nuclear receptors]]
==== DBD (DNA Binding Domain) ====
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>
==== LBD (Ligand Binding Domain) ====
<StructureSection load='1ie8' size='350' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1ie8]])' scene=''>


The LBD of a nuclear receptor has a common three layer sandwich
The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
It is a globular domain, mainly alpha
<scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
composed of
<scene name='Nuclear_receptor/Nr-lbd-alpha/1'>12 alpha-helices</scene>
arranged in a three layered sandwich, and a <scene name='Nuclear_receptor/Nr-lbd-beta/1'>beta-sheet</scene>.


</StructureSection>
</StructureSection>
<references/>
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