Nuclear receptor: Difference between revisions

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As exposed in the nuclear receptors facts book
''the nuclear receptors facts book''
<ref>Vincent Laudet, Hinrich Gronemeyer,
<ref>Vincent Laudet, Hinrich Gronemeyer,
"The nuclear receptor factsbook",  
"The nuclear receptor factsbook",  
Publisher Academic Press, 2002,
Publisher Academic Press, 2002
ISBN 0124377351, 9780124377356
</ref>
</ref>


== Structure ==
SEE [[Nuclear receptors]]
 
=== DBD (DNA Binding Domain) ===
=== LBD (Ligand Binding Domain) ===
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>


The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
It is completely folded and composed of a beta-sheet, and 12 alpha-helices arranged in a three layered sandwich.
It is a globular domain, mainly alpha
<scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
composed of  
<scene name='Nuclear_receptor/Nr-lbd-alpha/1'>12 alpha-helices</scene>
arranged in a three layered sandwich, and a <scene name='Nuclear_receptor/Nr-lbd-beta/1'>beta-sheet</scene>.


</StructureSection>
</StructureSection>
<references/>
<references/>

Latest revision as of 16:36, 25 January 2021

the nuclear receptors facts book [1]

SEE Nuclear receptors

Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry 1ie8)

Drag the structure with the mouse to rotate
  1. ↑ Vincent Laudet, Hinrich Gronemeyer, "The nuclear receptor factsbook", Publisher Academic Press, 2002

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