Nuclear receptor: Difference between revisions

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== Structure ==
SEE [[Nuclear receptors]]
 
=== DBD (DNA Binding Domain) ===
=== LBD (Ligand Binding Domain) ===
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>


The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
It is a globular domain<scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
It is a globular domain, mainly alpha
and composed of a beta-sheet, and 12 alpha-helices arranged in a three layered sandwich.
<scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
composed of  
<scene name='Nuclear_receptor/Nr-lbd-alpha/1'>12 alpha-helices</scene>
arranged in a three layered sandwich, and a <scene name='Nuclear_receptor/Nr-lbd-beta/1'>beta-sheet</scene>.


</StructureSection>


</StructureSection>
<references/>
<references/>

Latest revision as of 16:36, 25 January 2021

the nuclear receptors facts book [1]

SEE Nuclear receptors

Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry 1ie8)

Drag the structure with the mouse to rotate
  1. ↑ Vincent Laudet, Hinrich Gronemeyer, "The nuclear receptor factsbook", Publisher Academic Press, 2002

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