4b95: Difference between revisions

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'''Unreleased structure'''


The entry 4b95 is ON HOLD
==pVHL-EloB-EloB-EloC complex_(2S,4R)-1-(2-chlorophenyl)carbonyl-N-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound==
<StructureSection load='4b95' size='340' side='right'caption='[[4b95]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4b95]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B95 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=UCK:(2S,4R)-1-(2-CHLOROPHENYL)CARBONYL-N-[(4-CHLOROPHENYL)METHYL]-4-OXIDANYL-PYRROLIDINE-2-CARBOXAMIDE'>UCK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b95 OCA], [https://pdbe.org/4b95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b95 RCSB], [https://www.ebi.ac.uk/pdbsum/4b95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b95 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>  The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>


Authors: Buckley, D.L., Gustafson, J.L., VanMolle, I., Roth, A.G., SeopTae, H., Gareiss, P.C., Jorgensen, W.L., Ciulli, A., Crews, C.M.
==See Also==
 
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
Description: pVHL-EloB-EloC complex_3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO1,2-.C. PYRAZOLE bound
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Buckley DL]]
[[Category: Ciulli A]]
[[Category: Crews CM]]
[[Category: Gareiss PC]]
[[Category: Gustafson JL]]
[[Category: Jorgensen WL]]
[[Category: Roth AG]]
[[Category: SeopTae H]]
[[Category: VanMolle I]]
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