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[[Image:4agh.png|left|200px]]


{{STRUCTURE_4agh| PDB=4agh | SCENE= }}
==Structural features of ssDNA binding protein MoSub1 from Magnaporthe oryzae==
<StructureSection load='4agh' size='340' side='right'caption='[[4agh]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4agh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyricularia_oryzae Pyricularia oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AGH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.787&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4agh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4agh OCA], [https://pdbe.org/4agh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4agh RCSB], [https://www.ebi.ac.uk/pdbsum/4agh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4agh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G4NEJ8_MAGO7 G4NEJ8_MAGO7]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The well studied general transcription cofactor Sub1/PC4 has multiple functions in transcription. It plays both a negative and a positive role in transcription initiation and is involved in elongation and downstream transcription processes and as a transcription reinitiation factor. MoSub1, a Sub1/PC4 orthologue from rice blast fungus, binds the single-stranded DNA dT(12) tightly with an affinity of 186 nM. The crystal structure of MoSub1 has been solved to 1.79 A resolution. The structure of the protein shows high similiarity to the structure of PC4 and it has a similar dimer interface and DNA-binding region to PC4, indicating that MoSub1 could bind DNA using the same motif as other proteins of the Sub1/PC4 family. There are two novel features in the MoSub1 structure: a region N-terminal to the DNA-binding domain and a C-terminal extension. The region N-terminal to the DNA-binding domain of MoSub1 turns back towards the DNA-binding site and may interact directly with DNA or the DNA-binding site. The C-terminal extension region, which is absent in PC4, may not be capable of interacting with DNA and is one possible reason for the differences between Sub1 and PC4.


===Structural features of ssDNA binding protein MoSub1 from Magnaporthe oryzae===
Structural features of the single-stranded DNA-binding protein MoSub1 from Magnaporthe oryzae.,Huang J, Zhao Y, Huang D, Liu H, Justin N, Zhao W, Liu J, Peng Y Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1071-6. Epub 2012 Aug 18. PMID:22948907<ref>PMID:22948907</ref>


{{ABSTRACT_PUBMED_22948907}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 4agh" style="background-color:#fffaf0;"></div>
[[4agh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnaporthe_oryzae Magnaporthe oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AGH OCA].
== References ==
[[Category: Magnaporthe oryzae]]
<references/>
[[Category: Huang, D.]]
__TOC__
[[Category: Huang, J.]]
</StructureSection>
[[Category: Liu, J.]]
[[Category: Large Structures]]
[[Category: Peng, Y.]]
[[Category: Pyricularia oryzae]]
[[Category: Zhao, Y.]]
[[Category: Huang D]]
[[Category: Ssdna binding protein]]
[[Category: Huang J]]
[[Category: Transcription]]
[[Category: Peng Y]]
[[Category: Zhao Y]]
[[Category: Liu J]]
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