4g84: Difference between revisions

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[[Image:4g84.jpg|left|200px]]


{{STRUCTURE_4g84| PDB=4g84 |  SCENE= }}
==Crystal structure of human HisRS==
<StructureSection load='4g84' size='340' side='right'caption='[[4g84]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4g84]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G84 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g84 OCA], [https://pdbe.org/4g84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g84 RCSB], [https://www.ebi.ac.uk/pdbsum/4g84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g84 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/HARS1_HUMAN HARS1_HUMAN] Usher syndrome type 3;Autosomal dominant Charcot-Marie-Tooth disease type 2W. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/HARS1_HUMAN HARS1_HUMAN] Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516).<ref>PMID:26072516</ref> <ref>PMID:29235198</ref>


===Crystal structure of human HisRS===
==See Also==
 
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
{{ABSTRACT_PUBMED_22958643}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[4g84]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G84 OCA].
</StructureSection>
[[Category: Histidine--tRNA ligase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Schimmel, P.]]
[[Category: Large Structures]]
[[Category: Wei, Z.]]
[[Category: Schimmel P]]
[[Category: Wu, J.]]
[[Category: Wei Z]]
[[Category: Yang, X L.]]
[[Category: Wu J]]
[[Category: Zhang, M.]]
[[Category: Yang X-L]]
[[Category: Zhou, J J.]]
[[Category: Zhang M]]
[[Category: Ligase]]
[[Category: Zhou JJ]]
[[Category: Synthetase]]
Retrieved from "https://proteopedia.org/4g84"