Enolase multiple sequence alignment: Difference between revisions
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This page is a supplement to [[Introduction to Evolutionary Conservation]]. The portion of the multiple sequence alignment (MSA) below with <span style="background:pink;"> a pink background </span> is enlarged on that page. | |||
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Multiple Sequence Alignment (MSA) for enolase, an enzyme in glycolysis. | Multiple Sequence Alignment (MSA) for enolase, an enzyme in glycolysis. | ||
Key: IDENTICAL(*) | Key: '''IDENTICAL'''(*) SIMILAR(.) different | ||
Consensus Percentage is set to 100%. | Consensus Percentage is set to 100%. | ||
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<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; | <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; | ||
mso-bidi-font-family:"Courier New"'> 1 ENO_DROME| | mso-bidi-font-family:"Courier New"'> 1 ENO_DROME| | ||
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ne<b>E</b>A<b>L</b>qtIve AIek<b>AG</b>fkpg 234<br> | ne<b>E</b>A<b>L</b>qtIve AIek<b>AG</b>fkpg 234<br> | ||
6 4ENL Yeast| Saccharomyces cerevisiae <b>H</b>n<b>L</b>ksLtkkR | 6 4ENL Yeast| Saccharomyces cerevisiae <b>H</b>n<b>L</b>ksLtkkR | ||
ygasagn<b>VGD</b> <b>EGG</b>v<b>AP</b>nIqt ae<b>E</b>A<b>L</b>dlIvd AIka<b>AG</b>-- 238</span></p> | ygasagn<b>VGD</b> <b>EGG</b>v<b>AP</b>nIqt ae<b>E</b>A<b>L</b>dlIvd AIka<b>AG</b>---- 238</span></p> | ||
<p class=MsoNormal><span | <p class=MsoNormal><span | ||
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<br> | <br> | ||
1 ENO_DROME| Drosophila melanogaster gkIeiGm<b>D</b>v<b>A</b> | 1 ENO_DROME| Drosophila melanogaster <span style="background:pink;"> gkIeiGm<b>D</b>v<b>A</b> | ||
A<b>SEF</b>Yk--d<b>G</b> q<b>Y</b>dLdfknek sdksqwlpad klanlykefi 285<br> | A<b>SEF</b>Yk--d<b>G</b></span> q<b>Y</b>dLdfknek sdksqwlpad klanlykefi 285<br> | ||
2 ENOA_HUMAN| | 2 ENOA_HUMAN| | ||
Homo sapiens dkVviGm<b>D</b>v<b>A</b> A<b>SEF</b>Fr--s<b>G</b> k<b>Y</b>dLdfksp- | Homo sapiens <span style="background:pink;"> dkVviGm<b>D</b>v<b>A</b> A<b>SEF</b>Fr--s<b>G</b></span> k<b>Y</b>dLdfksp- | ||
ddpsryispd qladlyksfi 283<br> | ddpsryispd qladlyksfi 283<br> | ||
3 ENO_METJA| Methanococcus janaschii deVvfAl<b>D</b>a<b>A</b> | 3 ENO_METJA| Methanococcus janaschii <span style="background:pink;"> deVvfAl<b>D</b>a<b>A</b> | ||
A<b>SEF</b>Yk--d<b>G</b> y<b>Y</b>yVegkk-- ------ltre elldyykalv 280<br> | A<b>SEF</b>Yk--d<b>G</b></span> y<b>Y</b>yVegkk-- ------ltre elldyykalv 280<br> | ||
4 ENO_ECOLI| | 4 ENO_ECOLI| | ||
Escherichia coli kdItlAm<b>D</b>c<b>A</b> A<b>SEF</b>Yk--d<b>G</b> k<b>Y</b>vLagegn- | Escherichia coli <span style="background:pink;"> kdItlAm<b>D</b>c<b>A</b> A<b>SEF</b>Yk--d<b>G</b></span> k<b>Y</b>vLagegn- | ||
----kaftse efthfleelt 280<br> | ----kaftse efthfleelt 280<br> | ||
5 ENO_BACSU| | 5 ENO_BACSU| | ||
Bacillus subtilis eeVklAm<b>D</b>a<b>A</b> S<b>SEF</b>Ynked<b>G</b> k<b>Y</b>hLsgeg-- | Bacillus subtilis <span style="background:pink;"> eeVklAm<b>D</b>a<b>A</b> S<b>SEF</b>Ynked<b>G</b></span> k<b>Y</b>hLsgeg-- | ||
----vvktsa emvdwyeelv 278<br> | ----vvktsa emvdwyeelv 278<br> | ||
6 4ENL Yeast| Saccharomyces cerevisiae gkVkiGl<b>D</b>c<b>A</b> | 6 4ENL Yeast| Saccharomyces cerevisiae <span style="background:pink;"> gkVkiGl<b>D</b>c<b>A</b> | ||
S<b>SEF</b>Fk--d<b>G</b> k<b>Y</b>dLdfknpn sdkskwltgp qladlyhslm 286</span></p> | S<b>SEF</b>Fk--d<b>G</b></span> k<b>Y</b>dLdfknpn sdkskwltgp qladlyhslm 286</span></p> | ||
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; | <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New"; | ||
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6 4ENL Yeast| Saccharomyces cerevisiae kl 436<br> | 6 4ENL Yeast| Saccharomyces cerevisiae kl 436<br> | ||
</span></p> | </span></p> | ||
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Summary of categories applied to a total of 436 residues in the PDB file sequence for a consensus level setting of 100%: | Summary of categories applied to a total of 436 residues in the PDB file sequence for a consensus level setting of 100%: | ||
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Definitions of SIMILAR groups of amino acids:<pre> | Definitions of SIMILAR groups of amino acids:<pre> | ||
ILV Ile Leu Val hydrophobic, aliphatic / medium-sized side-chain | ILV Ile Leu Val hydrophobic, aliphatic / medium-sized side-chain | ||
FWY Phe Trp Tyr | FWY Phe Trp Tyr hydrophobic, aromatic / large side-chain (Tyr polar) | ||
KRH Lys Arg His | KRH Lys Arg His + charge | ||
DE Asp Glu | DE Asp Glu - charge | ||
GAS Gly Ala Ser | GAS Gly Ala Ser small | ||
P Pro | P Pro helix breaking | ||
C Cys | C Cys disulfide-forming | ||
TNQM Thr Asn Gln Met polar (except Met) | TNQM Thr Asn Gln Met polar (except Met) | ||
</pre> | </pre> | ||
