4gpu: Difference between revisions

==Crystal structure of K. lactis Dxo1 (YDR370C) in complex with manganese==

<StructureSection load='4gpu' size='340' side='right'caption='[[4gpu]], [[Resolution|resolution]] 2.80&Aring;' scene=''>

== Structural highlights ==

<table><tr><td colspan='2'>[[4gpu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GPU FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gpu OCA], [https://pdbe.org/4gpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gpu RCSB], [https://www.ebi.ac.uk/pdbsum/4gpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gpu ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/DXO1_KLULA DXO1_KLULA] Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs.<ref>PMID:22961381</ref>

[[Category: Kluyveromyces lactis NRRL Y-1140]]

[[Category: Large Structures]]

[[Category: Chang JH]]

[[Category: Tong L]]