3r0n: Difference between revisions

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[[Image:3r0n.png|left|200px]]


{{STRUCTURE_3r0n| PDB=3r0n | SCENE= }}
==Crystal Structure of the Immunoglobulin variable domain of Nectin-2==
<StructureSection load='3r0n' size='340' side='right'caption='[[3r0n]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3r0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R0N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r0n OCA], [https://pdbe.org/3r0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r0n RCSB], [https://www.ebi.ac.uk/pdbsum/3r0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r0n ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Nectins are members of the Ig superfamily that mediate cell-cell adhesion through homophilic and heterophilic interactions. We have determined the crystal structure of the nectin-2 homodimer at 1.3 A resolution. Structural analysis and complementary mutagenesis studies reveal the basis for recognition and selectivity among the nectin family members. Notably, the close proximity of charged residues at the dimer interface is a major determinant of the binding affinities associated with homophilic and heterophilic interactions within the nectin family. Our structural and biochemical data provide a mechanistic basis to explain stronger heterophilic versus weaker homophilic interactions among these family members and also offer insights into nectin-mediated transinteractions between engaging cells.


===Crystal Structure of the Immunoglobulin variable domain of Nectin-2===
Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.,Samanta D, Ramagopal UA, Rubinstein R, Vigdorovich V, Nathenson SG, Almo SC Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14836-40. Epub 2012 Aug 27. PMID:22927415<ref>PMID:22927415</ref>


{{ABSTRACT_PUBMED_22927415}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3r0n" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
[[3r0n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R0N OCA].
*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almo, S C.]]
[[Category: Large Structures]]
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
[[Category: Almo SC]]
[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
[[Category: Nathenson SG]]
[[Category: Nathenson, S G.]]
[[Category: Ramagopal UA]]
[[Category: Ramagopal, U A.]]
[[Category: Samanta D]]
[[Category: Samanta, D.]]
[[Category: Cell adhesion]]
[[Category: Cell-adhesion molecule]]
[[Category: Ig-domain]]
[[Category: New york structural genomics research consortium]]
[[Category: Nysgrc]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
[[Category: Virus entry receptor]]
Retrieved from "https://proteopedia.org/3r0n"