1kh6: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(12 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1kh6.gif|left|200px]]<br /><applet load="1kh6" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1kh6, resolution 2.9&Aring;" />
'''Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.'''<br />


==Overview==
==Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.==
The hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA drives internal initiation of viral protein synthesis during host cell infection. In the tertiary structure of the IRES RNA, two helical junctions create recognition sites for direct binding of the 40S ribosomal subunit and eukaryotic initiation factor 3 (eIF3). The 2.8 A resolution structure of the IIIabc four-way junction, which is critical for binding eIF3, reveals how junction nucleotides interact with an adjacent helix to position regions directly involved in eIF3 recognition. Two of the emergent helices stack to form a nearly continuous A-form duplex, while stacking of the other two helices is interrupted by the insertion of junction residues into the helix minor groove. This distorted stack probably serves as an important recognition surface for the translational machinery.
<StructureSection load='1kh6' size='340' side='right'caption='[[1kh6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1kh6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KH6 FirstGlance]. <br>
1KH6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KH6 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kh6 OCA], [https://pdbe.org/1kh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kh6 RCSB], [https://www.ebi.ac.uk/pdbsum/1kh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kh6 ProSAT]</span></td></tr>
Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation., Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA, Nat Struct Biol. 2002 May;9(5):370-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11927953 11927953]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Doudna, J A.]]
</StructureSection>
[[Category: Grech, A.]]
[[Category: Large Structures]]
[[Category: Jubin, R]]
[[Category: Doudna JA]]
[[Category: Kieft, J S.]]
[[Category: Grech A]]
[[Category: Zhou, K.]]
[[Category: Jubin R]]
[[Category: bromine]]
[[Category: Kieft JS]]
[[Category: four-way junction]]
[[Category: Zhou K]]
[[Category: hcv]]
[[Category: ires]]
[[Category: rna structure]]
[[Category: translation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:34:05 2008''
Retrieved from "https://proteopedia.org/1kh6"