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[[Image:3nf5.png|left|200px]]


{{STRUCTURE_3nf5| PDB=3nf5 | SCENE= }}
==Crystal structure of the C-terminal domain of nuclear pore complex component NUP116 from Candida glabrata==
<StructureSection load='3nf5' size='340' side='right'caption='[[3nf5]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3nf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NF5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nf5 OCA], [https://pdbe.org/3nf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nf5 RCSB], [https://www.ebi.ac.uk/pdbsum/3nf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nf5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6FU56_CANGA Q6FU56_CANGA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/3nf5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nf5 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The nuclear pore complex (NPC), embedded in the nuclear envelope, is a large, dynamic molecular assembly that facilitates exchange of macromolecules between the nucleus and the cytoplasm. The yeast NPC is an eightfold symmetric annular structure composed of ~456 polypeptide chains contributed by ~30 distinct proteins termed nucleoporins. Nup116, identified only in fungi, plays a central role in both protein import and mRNA export through the NPC. Nup116 is a modular protein with N-terminal "FG" repeats containing a Gle2p-binding sequence motif and a NPC targeting domain at its C-terminus. We report the crystal structure of the NPC targeting domain of Candida glabrata Nup116, consisting of residues 882-1034 [CgNup116(882-1034)], at 1.94 A resolution. The X-ray structure of CgNup116(882-1034) is consistent with the molecular envelope determined in solution by small-angle X-ray scattering. Structural similarities of CgNup116(882-1034) with homologous domains from Saccharomyces cerevisiae Nup116, S. cerevisiae Nup145N, and human Nup98 are discussed.


===Crystal structure of the C-terminal domain of nuclear pore complex component NUP116 from Candida glabrata===
Atomic structure of the nuclear pore complex targeting domain of a Nup116 homologue from the yeast, Candida glabrata.,Sampathkumar P, Kim SJ, Manglicmot D, Bain KT, Gilmore J, Gheyi T, Phillips J, Pieper U, Fernandez-Martinez J, Franke JD, Matsui T, Tsuruta H, Atwell S, Thompson DA, Emtage JS, Wasserman SR, Rout MP, Sali A, Sauder JM, Almo SC, Burley SK Proteins. 2012 Aug;80(8):2110-6. doi: 10.1002/prot.24102. Epub 2012 Jun 4. PMID:22544723<ref>PMID:22544723</ref>


{{ABSTRACT_PUBMED_22544723}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3nf5" style="background-color:#fffaf0;"></div>
[[3nf5]] is a 2 chain structure of [[Nucleoporin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF5 OCA].


==See Also==
==See Also==
*[[Nucleoporin|Nucleoporin]]
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
[[Category: Atwell, S.]]
== References ==
[[Category: Bain, K.]]
<references/>
[[Category: Burley, S K.]]
__TOC__
[[Category: Emtage, J S.]]
</StructureSection>
[[Category: Gheyi, T.]]
[[Category: Large Structures]]
[[Category: Gilmore, J.]]
[[Category: Atwell S]]
[[Category: Manglicmot, D.]]
[[Category: Bain K]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
[[Category: Burley SK]]
[[Category: Rout, M.]]
[[Category: Emtage JS]]
[[Category: Sali, A.]]
[[Category: Gheyi T]]
[[Category: Sampathkumar, P.]]
[[Category: Gilmore J]]
[[Category: Sauder, J M.]]
[[Category: Manglicmot D]]
[[Category: Thompson, D A.]]
[[Category: Rout M]]
[[Category: Wasserman, S.]]
[[Category: Sali A]]
[[Category: Glebs domain]]
[[Category: Sampathkumar P]]
[[Category: New york sgx research center for structural genomic]]
[[Category: Sauder JM]]
[[Category: New york structural genomix research consortium]]
[[Category: Thompson DA]]
[[Category: Nuclear pore complex]]
[[Category: Wasserman S]]
[[Category: Nup116]]
[[Category: Nysgxrc]]
[[Category: Protein structure initiative]]
[[Category: Protein transport]]
[[Category: Psi-2]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/3nf5"