4hdc: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4hdc is ~~ON HOLD~~

==Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (TMK: Compound 41)==

== Structural highlights ==

<table><tr><td colspan='2'>[[4hdc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HDC OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4HDC FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13Y:2-(3-CHLOROPHENOXY)-4-{(1R)-3-METHYL-1-[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]BUTYL}BENZOIC+ACID'>13Y</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4hdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hdc OCA], [https://pdbe.org/4hdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hdc RCSB], [https://www.ebi.ac.uk/pdbsum/4hdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hdc ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/KTHY_STAAN KTHY_STAAN] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.[HAMAP-Rule:MF_00165]

~~Authors~~: ~~Olivier, N.B~~.

==See Also==

*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]

~~Description~~: ~~Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (TMK: Compound 41~~

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Staphylococcus aureus subsp. aureus N315]]

[[Category: Olivier NB]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4hdc is ON HOLD
+==Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (TMK: Compound 41)==
+<StructureSection load='4hdc' size='340' side='right'caption='[[4hdc]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4hdc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HDC FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13Y:2-(3-CHLOROPHENOXY)-4-{(1R)-3-METHYL-1-[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]BUTYL}BENZOIC+ACID'>13Y</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hdc OCA], [https://pdbe.org/4hdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hdc RCSB], [https://www.ebi.ac.uk/pdbsum/4hdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hdc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KTHY_STAAN KTHY_STAAN] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.[HAMAP-Rule:MF_00165]
-Authors: Olivier, N.B.
+==See Also==
+*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
-Description: Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (TMK: Compound 41
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Staphylococcus aureus subsp. aureus N315]]
+[[Category: Olivier NB]]