Heat shock factor: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='3hts' size='400' side='right' caption='Structure of heat shock protein complex with DNA (PDB entry 3hts)' scene=''> '''Heat shock factor''' (HSF) are tran... |
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<StructureSection load='3hts' size='400' side='right' caption='Structure the dimeric heat shock protein complex with DNA and glycerol (PDB entry [[3hts]])' scene='51/516471/Cv/3'> | |||
== Function == | |||
'''Heat shock factor''' (HSF) are transcriptional activators of heat shock genes. HSF bind to heat shock sequence elements throughout the genome with a consensus array of three oppositely oriented sequence AGGAN and activate transcription. Each HSF monomer contains one C-terminal and 3 N-terminal leucine zippers. Two sequences flanking the N-terminal leucine zippers contain the consensus nuclear localization signal (NLS). The DNA-binding domain (DBD residues 193-281) of HSF lies in the N-terminal of the first NLS region<ref>PMID:8441385</ref>. | |||
== Relevance == | |||
Depletion of HSF-1 is associated with accumulation of pathogenic androgen receptor in neurodegenerative diseases<ref>PMID:23360996</ref>. Increased expression of HSF-1 contributes to the reversal of cerebellar cell deficiency in rats carrying Alzheimer disease<ref>PMID:23665061</ref>. | |||
== Structural highlights == | |||
The DBD region of HSF shows <scene name='51/516471/Cv/4'>multiple protein-DNA interactions as well as water-mediated interactions</scene> <ref>PMID:10331875</ref>. Water molecules shown as red spheres. | |||
==3D structures of heat shock factor== | ==3D structures of heat shock factor== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[2ldu]] – hHSF-1 DBD residues 193-281 – human - NMR<br /> | |||
[[5hdg]] – hHSF-1 DBD <br /> | |||
[[5d5u]], [[5d5v]], [[5hdn]], [[7dcj]], [[7dcs]], [[7dct]] – hHSF-1 DBD + DNA<br /> | |||
[[5hdk]] – hHSF-2 DBD <br /> | |||
[[5d8k]], [[5d8l]], [[7dci]], [[7dcu]] – hHSF-2 DBD + DNA<br /> | |||
[[6j6v]] – hHSF-4 DBD <br /> | |||
[[6j6w]] – hHSF-4 DBD (mutant)<br /> | |||
[[8zys]] – hHSF-5 DBD + DNA<br /> | |||
[[1fbu]], [[2hts]] – KlHSF DBD – ''Kluyveromyces lactis'' | |||
[[1fbq]], [[1fbs]], [[3htf]] – KlHSF DBD (mutant) | |||
[[3hsf]] - KlHSF DBD (mutant) – NMR<br /> | |||
[[3hts]] – KlHSF DBD + DNA<br /> | |||
[[1fyk]], [[1fyl]], [[1fym]] – KlHSF DBD (mutant) + DNA<br /> | |||
[[1hks]], [[1hkt]] – HSF DBD – ''Drosophila melanogaster'' – NMR<br /> | [[1hks]], [[1hkt]] – HSF DBD – ''Drosophila melanogaster'' – NMR<br /> | ||
== References == | |||
<references/> | |||
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