4gr0: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4gr0 is ~~ON HOLD until Paper Publication~~

==Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B==

== Structural highlights ==

<table><tr><td colspan='2'>[[4gr0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR0 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4GR0 FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.497Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=R4B:N-[(2S)-3-[(R)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALANYL-L-ALANINAMIDE'>R4B</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4gr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gr0 OCA], [https://pdbe.org/4gr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gr0 RCSB], [https://www.ebi.ac.uk/pdbsum/4gr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gr0 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

~~Authors~~: ~~Stura, E.A., Vera, L.,~~ Beau, F~~., Devel, L.,~~ Cassar-Lajeunesse, E., Dive, V.

==See Also==

*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]

~~Description~~: ~~Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B~~

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Beau F]]

[[Category: Cassar-Lajeunesse E]]

[[Category: Devel L]]

[[Category: Dive V]]

[[Category: Stura EA]]

[[Category: Vera L]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4gr0 is ON HOLD  until Paper Publication
+==Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B==
+<StructureSection load='4gr0' size='340' side='right'caption='[[4gr0]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4gr0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GR0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.497&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=R4B:N-[(2S)-3-[(R)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALANYL-L-ALANINAMIDE'>R4B</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gr0 OCA], [https://pdbe.org/4gr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gr0 RCSB], [https://www.ebi.ac.uk/pdbsum/4gr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gr0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
-Authors: Stura, E.A., Vera, L., Beau, F., Devel, L., Cassar-Lajeunesse, E., Dive, V.
+==See Also==
+*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
-Description: Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Beau F]]
+[[Category: Cassar-Lajeunesse E]]
+[[Category: Devel L]]
+[[Category: Dive V]]
+[[Category: Stura EA]]
+[[Category: Vera L]]