4hca: Difference between revisions
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==DNA binding by GATA transcription factor-complex 1== | |||
<StructureSection load='4hca' size='340' side='right'caption='[[4hca]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hca]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HCA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hca OCA], [https://pdbe.org/4hca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hca RCSB], [https://www.ebi.ac.uk/pdbsum/4hca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hca ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/GATA3_HUMAN GATA3_HUMAN] Precursor B-cell acute lymphoblastic leukemia;Hypoparathyroidism - deafness - renal disease. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GATA3_HUMAN GATA3_HUMAN] Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.<ref>PMID:23824597</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bates DL]] | |||
[[Category: Chen L]] | |||
[[Category: Chen Y]] | |||
[[Category: Dey R]] | |||
Latest revision as of 11:36, 1 March 2024
DNA binding by GATA transcription factor-complex 1
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